MausDB: An open source application for phenotype data and mouse colony...
AbstractBackgroundLarge-scale, comprehensive and standardized high-throughput mouse phenotyping has been established as a tool of functional genome research by the German Mouse Clinic and others. In...
View ArticleThe German Mouse Clinic – Running an Open Access Platform
AbstractNext challenges in functional annotation of mammalian genomes are yet of a much larger scope than previous genomics initiatives. Mouse mutant resources must be phenotyped systematically (one...
View ArticleMouse large-scale phenotyping initiatives: overview of the European Mouse...
AbstractTwo large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with...
View ArticleInnovations in phenotyping of mouse models in the German Mouse Clinic
AbstractUnder the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular...
View ArticlePrinciples and application of LIMS in mouse clinics
Abstract Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually...
View ArticleAssistenzsysteme in neuer Dimension
ZusammenfassungSicherheit ist ein Kernwert von Mercedes-Benz, den auch die neue E-Klasse eindrucksvoll verkörpert. Mit dem neuen Modell feiern viele Innovationen Weltpremiere. Vor allem das...
View ArticleCosts of Implementing Quality in Research Practice
AbstractUsing standardized guidelines in preclinical research has received increased interest in light of recent concerns about transparency in data reporting and apparent variation in data quality, as...
View ArticleA comprehensive and comparative phenotypic analysis of the collaborative...
AbstractThe collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here,...
View ArticleObjective hearing threshold identification from auditory brainstem response...
AbstractHearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological...
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Echo2Pheno: a deep-learning application to uncover echocardiographic...
AbstractEchocardiography, a rapid and cost-effective imaging technique, assesses cardiac function and structure. Despite its popularity in cardiovascular medicine and clinical research, image-derived...
View ArticleAnalysis of mammalian gene function through broad-based phenotypic screens...
Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions...
View ArticleIdentification of genetic elements in metabolism by high-throughput mouse...
AbstractMetabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to...
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